Polycystic ovary syndrome etiology pathogenesis and diagnosis pdf

Department of pharmacology and toxicology, swamy vivekanandha college of pharmacy, tiruchengode, namakkal, tamil nadu 637 205, india. Polycystic ovary syndrome pcos, like numerous complex diseases, has a multifaceted etiology and pathophysiology, and it is associated with hormonal and metabolic impairments, ovarian. Polycystic ovary syndrome is the most common endocrinopathy among reproductiveaged women in. Full text genetic basis of polycystic ovary syndrome pcos. It is characterized by clinical andor biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged andor polycystic ovaries in ultrasound images 12 or more small bubbles located circumferentially andor ovarian volume 10 ml. Polycystic ovarian syndrome pcos is one of the most common female endocrine disorders. The diagnosis of pcos has lifelong implications, with increased risk for infertility, metabolic syndrome, and type 2 diabetes mellitus, and possibly for cardiovascular disease and endometrial carcinoma. The rotterdam eshreasrmsponsored pcos consensus work shop group. Polycystic ovary syndrome pcos is a common endocrine disorder in females, especially in women of reproductive age. The name of the condition comes from the appearance of numerous small cysts along the outer edge of each ovary and enlarged ovaries. The pathogenesis and treatment of polycystic ovary syndrome. The disorder is diagnosed if 2 of the 3 specified conditions are met. Polycystic ovary syndrome pcos is a heterogeneous disorder of uncertain aetiology, which affects between 6 and 10% of women of the reproductive age.

The aetiology of this syndrome remains largely unknown, but mounting evidence suggests that pcos. The diagnosis of polycystic ovary syndrome has emerged. Polycystic ovary syndrome pcos is the most common endocrine disorder in reproductive aged women, with a prevalence between 5% and 15%, depending on the diagnostic criteria applied 1, 2. Various diagnostic criteria have been proposed, generally centered. Various diagnostic criteria have been proposed, generally centered around the features of hyperandrogenism andor hyperandrogenemia, oligoovulation and polycystic ovarian morphology. Mental health disorders including depression, anxiety, bipolar. Although the pathophysiology of the syndrome is complex and there is no single defect from which it is. Polycystic ovary syndrome pcos accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women.

Due to the complex pathophysiology involving multiple pathways and proteins, single. Polycystic ovary syndrome pcos, also known as the steinleventhal syndrome, is one of the most common endocrinopathies among women of reproductive age. It is clear that the underlying pathophysiology of pcos is not fully. Polycystic ovary syndrome pcos is the most common endocrine disorder among female in reproductive age. Polycystic ovary syndrome pcos is currently the leading cause of menstrual complications in women. Diagnosis and treatment of polycystic ovary syndrome american. Heterogeneous by nature, pcos is defined by a combination of signs and symptoms of androgen excess and ovarian dysfunction in the absence of other specific diagnoses. When defined as otherwise unexplained hyperandrogenic oligoanovulation, twothirds of pcos cases have functionally. The pathophysiology of pcos is yet to be fully understood. Polycystic ovary syndrome pcos was hypothesized to result from functional ovarian hyperandrogenism foh due to dysregulation of androgen secretion in 19891995.

Fogue and massabuau proposed 3 potential mechanisms. The heterogeneity of both the ovarian morphology and clinical. Polycystic ovary syndrome pcos is one of the most common endocrine and metabolic disorders in premenopausal women. Development of an animal model for polycystic ovarian. Development of an animal model for polycystic ovarian syndrome in relation to reproductive and metabolic phenotype. Polycystic ovary syndrome pcos, a complex genetic condition, is a highly prevalent heterogeneous syndrome of clinical andor biochemical androgen excess, ovulatory dysfunction and polycystic. In pcos, the eggs in these follicles do not mature and are not released from the ovaries. Polycystic ovary syndrome pcos is one of the most common endocrine metabolic disorders affecting about 5% women of reproductive age 1. Epidemiology, diagnosis, and management of polycystic ovary. There are several mechanisms that have been suggested to play a role in the pathogenesis of pcos, including hormonal.

Three major pathophysiologic hypotheses have been proposed to explain the clinical findings of polycystic ovary syndrome pcos related to three major laboratory findings. Subsequent studies have supported and amplified this hypothesis. Matalliotakis i1, kourtis a, koukoura o, panidis d. Revised consensus on diagnostic criteria and longterm health risk. An abnormality in the ovaries is the primary cause of the disorder, but additional agents, such as obesity and. Department of pharmacology, vinayaka missons college of pharmacy, vinayaka. The pathogenesis of polycystic ovary syndrome pcos is not precisely known. The pathogenesis and treatment of polycystic ovary.

Pcos could be diagnosed by infertility, acne, amenorrhea or. Polycystic ovary syndrome pcos is the most common endocrinopathy in women of reproductive age, with a prevalence of up to 10%. Pathophysiology and infertility article pdf available in world journal of laparoscopic surgery 71. Pcos was first described by stein and leventhal as a syndrome of oligoamenorrhea and polycystic ovaries that was variably accompanied by hirsutism, acne, and obesity 3, 4. Etiology, pathogenesis and diagnosis polycystic ovary syndrome pcos is the most common endocrinopathy in.